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Research

In any given biological sample, there are thousands of small molecule metabolites, with concentrations spanning many orders of magnitude. Metabolomics is the study concerned with detecting and identifying small molecule metabolites in biological samples. Chromatography is the tool best suited for this task, however, traditional one-dimensional chromatographic separations cannot fully separate all the metabolites in a biological sample. To increase chromatographic resolution, multidimensional separations are often employed, but these remain underutilized in the field of metabolomics.

Our group’s research will focus on the development of methodologies for performing untargeted metabolomics using comprehensive two-dimensional liquid chromatography mass spectrometry (LC×LC-MS) for studying the metabolome in a wide variety of biological samples. We will be addressing both basic and applied research questions in chromatography, mass spectrometry, and metabolomics. Our group will also focus on developing chemometric, quality control approaches, and data tools for processing data from LC×LC-MS based metabolomics experiments, with broader applications to metabolomics data from other instrumental platforms.

My current research website is .

Teaching

Ryland’s teaching interests are in analytical chemistry, metabolomics, and chemometrics.